白色至类白色结晶，95-97℃，沸点262.4℃，折射率1.599，闪点112.5℃，密度1.649g/cm3，溶于水。

生产方法:将100g（1.0mol）丁二酸酐和70g（1.0mol）盐酸羟胺一起加热，使反应系统保持负压抽除生成的挥发物，迅速加热至125℃以上，1h后慢慢升至160℃。停止加热，当温度降至125℃时，将液态反应物倾入400ml乙醚中并激烈搅拌。产物固化后倾去乙醚层，固化物与400ml丁醇共热至沸，热滤，滤液迅速冷却至0℃。1h后过滤，结晶依次用丁醇、乙醚洗涤，所得粗品用乙酸乙酯重结晶，得50g成品，收率44%。

产品质量
指标名 　　　　指标
外观 　　　　　白色晶体
含量 　　　　　98%
熔点 　　　　　173-175(℃) 
干燥失重 　　　≤1.5% 

用途:活化羧基以用于酰胺键的形成。用于合成氨基酸保护剂、半合成卡那霉素及医药中间体。 碳二亚胺法的添加剂，用于促进酰胺化和肽偶联反应。

 其它信息：

Product Identification
【Product Name】1-Hydroxy-2,5-pyrrolidinedione N-羟基丁二酰亚胺
【Synonyms】1-Hydroxypyrrolidine-2,5-dione
【CAS】6066-82-6
【Formula】C4H5NO3
【Molecular Weight】115.09
【EINECS】228-001-3
【Beilstein/Gmelin】113913
【Beilstein Reference】5-21-09-00498

Physical and Chemical Properties
【Appearance】White.
【Solubility in water】Soluble
【Melting Point】93 - 95
【Boiling Point】363
【Partition Coefficient】-.87

First Aid Measures
【Ingestion】Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately.
【Skin】Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.

Handling and Storage
【Storage】Store in a cool, dry place. Keep container closed when not in use.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
【Respirators】Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
【Exposure Effects】The toxicological properties of this material have not been investigated.

Fire Fighting Measures
【Flash Point】175
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures
【Small spills/leaks】Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal.
Stability and Reactivity
【Disposal Code】3
【Stability】Stable under normal temperatures and pressures.
【Incompatibilities】Strong oxidizing agents - acid chlorides - acid anhydrides - strong bases - moisture.
【Decomposition】Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Transport Information
【HS Code】2925 19 95

Hazards Identification
【EC Risk Phrase】R 5 36/37/38
【EC Safety Phrase】S 26 36