4-吡啶甲酸_厂家推荐

结构式
　　　　

CAS： 55-22-1
分子式： C6H5NO2
分子量： 123.11

中文名称：吡啶-4-甲酸
                      异烟酸
                      4-吡啶甲酸
                      异尼克酸
                       托灭酸

英文名称： isonicotinic acid
                      4-carboxypyridine
                      4-picolinic acid
                      4-pyridinecarboxylic acid
                      acide iso-nicotinique
                      iso-Nicotinic acid

性状描述：白色针状结晶。熔点319℃（315℃）。较溶于热水，水溶液的pH值为3.6，异烟酸微溶于冷水，几乎不溶于沸醇、苯及醚。能升华，无气味。

用途：用作医药中间体，主要用于制抗结核病药物异烟肼，也用于合成酰胺、酰肼、酯类等衍生物。

其它信息：
【Product Name】Isonicotinic acid 异烟酸;4-吡啶甲酸
【Synonyms】4-Carboxypyridin
【CAS】55-22-1
【Formula】C6H5NO2
【Molecular Weight】123.11
【EINECS】200-228-2
【RTECS】NS1103000
【RTECS Class】Drug
【Merck】13,5206
【Beilstein/Gmelin】109599
【Beilstein Reference】5-22-02-00188
【EC Class】irritant

Physical and Chemical Properties
【Appearance】Off white to beige-yellow powder.
【Solubility in water】Very soluble
【Boiling Point】396
【Vapor Pressure】6E-7 (25 C)
【pKa/pKb】1.94 (pKa)
【Partition Coefficient】.54
【Heat Of Vaporization】68.2 kJ/mol
【Heat Of Combustion】-2724 kJ/mol
【Vapor Density】4.2

First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Get medical aid immediately. Extensive irrigation is required (at least 30 minutes).

Handling and Storage
【Storage】Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Hazards Identification
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
【Inhalation】May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
【Skin】May cause skin irritation. The toxicological properties of this material have not been fully investigated.
【Eyes】May cause eye irritation. May cause eye irritation and possible damage.
【EC Risk Phrase】R 36/37/38
【EC Safety Phrase】S 26 36

Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures
【Flash Point】193
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures
【Small spills/leaks】Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity
【Disposal Code】4
【Incompatibilities】Oxidizing agents.
【Stability】Stable under normal temperatures and pressures.
【Decomposition】Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Transport Information
【HS Code】2933 39 99